Appeal No. 93-3623 Page 14
Application 07/629,690
comprise peptide coated porous silica objects." (Emphasis
added.)
Hrdina
38. Hrdina teaches the use of porous, inert particles for
packing the reactor of an amino acid analyzer. (2:27-35.)
Urdea
39. Urdea teaches the use of solid-phase supports for
polypeptides in the reaction chamber, specifically beads or
particles. Such supports should be porous and chemically inert.
Urdea specifically teaches the use of silica beads (e.g.,
Fractosil ) as the preferred support. (4:60-5:9.)®
Johnson
40. Alternatively, we further note the teachings of, e.g.,
Johnson that discrete, amorphous silica microparticles are a
conventional support for peptides. (6:43-7:2.) Johnson also
teaches coating the silica particulate substrate with protein.
(7:28-39.) We recognize that Johnson is not directed to a
peptide sequencing per se, but it is directed to selective
binding and elution in a continuous-flow reactor and is thus
sufficiently related to the problem facing the inventor to be
instructive to a person having ordinary skill in the art.
41. We find that Appellant provides no basis for us to
evaluate his declaration that Johnson is not analogous. (Decl. I
at ¶ 12(ii).) As explained in the preceding paragraph, Johnson
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