Ex parte MOROZUMI et al. - Page 3




          Appeal No. 95-3056                                                           
          Application 07/833,718                                                       
          § 1.192(c)(5)(October 22, 1993).  Claim 1 reads:                             
                    1.   Solid 2-octynyl adenosine having a water content              
               of not more than 3%.                                                    
          2.   Examiner’s findings                                                     
               A.   The examiner finds that each of Miyasaka and Matsuda               
          describe 2-octynyl adenosine (Ans., p. 5, l. 19-20).                         
               B.   The examiner finds that Weygand describes “processes               
          commonly used by the practitioner to produce and isolate                     
          compounds which are free from impurities, i.e.,                              
          recrystallization from anhydrous solvents, drying under vacuum               
          at temperatures above ambient, etc.” (Ans., p. 5, l. 21-24).                 
               C.   The examiner finds that Miyasaka and Matsuda                       
          isolated 2-octynyl adenosine as a “hydrate” (Ans., p. 5, l.                  
          27-28).                                                                      
               D.   The examiner finds that 2-octynyl adenosine hydrates               
          are not patentably distinct from anhydrous 2-octynyl adenosine               
          (Ans., pp. 5-6, bridging sentence).                                          
               E.   Based on Morozumi’s Declarations Under 37 CFR 1.132,               
          filed July 6, 1993 (Paper No. 14) and April 13, 1994 (Paper                  
          No. 21 ) and accompanying remarks, the examiner finds that1/2                                                                    
          persons having ordinary skill in the art would have known that               
          “practical production of 2-octynyladenosine on large scale was               

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