Ex parte MOROZUMI et al. - Page 7




          Appeal No. 95-3056                                                           
          Application 07/833,718                                                       
               Second, whether or not applicants solved “a very simple                 
          problem” (Ans., p. 7, l. 6-7) “is not inimical to                            
          patentability.”  In re Oetiker, 977 F.2d 1443, 1447, 24 USPQ2d               
          1443, 1446 (Fed. Cir. 1992).  Oetiker also instructs at 1447,                
          25 USPQ2d at 1446:                                                           
               See Goodyear Tire & Rubber Co. v. Ray-O-Vac Co., 321 U.S.               
               275, 279, [60 USPQ 386, 388] (1944)(simplicity of itself                
               does      not negate invention); Panduit Corp. v. Dennison              
          Mfg       Co.,      810 F.2d 1561, 1572, 1 USPQ2d 1593, 1600                 
          (Fed.     Cir.)(the      patent system is not foreclosed to                  
          those who make      simple inventions), cert. denied, 481 U.S.               
          1052 (1987).                                                                 
               Third, In re Sponnoble, 405 F.2d 578, 160 USPQ 237 (CCPA                
          1969), teaches at 585, 160 USPQ at 243:                                      
               . . . [A] patentable invention may lie in the discovery                 
               of the source of a problem even though the remedy may be                
               obvious once the source of the problem is identified.                   
               This is part of the “subject matter as a whole” which                   
               should always be considered in determining the                          
          obviousness                                                                  
               of an invention under 35 U.S.C. § 103.                                  
          Here, the examiner finds, based on applicants’ own disclosure                
          and declaratory evidence, that (1) the 2-octynyl adenosines                  
          which Miyasaka and Matsuda isolated are both hydrates (Ans.,                 
          p. 5,                                                                        
          l. 27-28), and (2) practical production of 2-octynyl adenosine               




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