Ex parte MOROZUMI et al. - Page 6




          Appeal No. 95-3056                                                           
          Application 07/833,718                                                       
          2-octynyl adenosine is clearly erroneous.  See the examples in               
          the specification and Morozumi’s Declaration Under 37 CFR                    
          1.132 filed July 6, 1993 (Paper No. 14), which establish by                  
          elemental and stability analysis that 2-octynyl adenosine                    
          monohydrate                                                                  
          (4.6% water) has markedly different properties from 2-octynyl                
          adenosines with a water content ranging from 3.14 to 0.93%.                  
          Compare In re Papesch, 315 F.2d 381, 391, 137 USPQ 43, 51                    
          (CCPA 1963):                                                                 
                    From the standpoint of patent law, a compound and                  
               all of its properties are inseparable; they are one and                 
               the same thing.                                                         
          Based on the comparative properties of the compounds, we find                
          that solid 2-octynyl adenosine monohydrate (4.6% water) is                   
          patentably distinct from solid 2-octynyl adenosines with a                   
          water content of not more than 3%.  While it may “not defy                   
          logic . . . that a compound of known chemical structure,                     
          initially isolated in hydrate form, should not be patentably                 
          distinguishable from the identical compound rendered                         
          anhydrous” (Ans., p. 6, l. 9-12), the greater weight of                      
          evidence of record in this case reasonably suggests the                      
          contrary.                                                                    


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