Ex Parte PARE - Page 7





                F 26. Par& 426 says that there is a need for a method of enhancing the volatility of the volatilizable                                                 
                          substances and for selectively separating the volatile component. P. Ex. 2002, col. 3). 11. 34                                               
                          47.                                                                                                                                          
                F 27. Par& 426 addresses the volatility problem by subjecting the substance to microwave radiation                                                     
                          to enhance the volatility of the desired substance. P. Ex. 2002, col. 2, 11. 13-23.                                                          
                F 28. Par6 426 describes a process in which a material containing the volatile component is placed                                                     
                          in a container which is then sealed with a selective semipermeable membrane, microwaves                                                      
                          are applied to effect volatilization and the desired volatile components are separated by                                                    
                          passing them through a semi-permeable membrane. P. Ex. 2002, col. 3,11. 43-58.                                                               
                F 29. The volatilization procedure is said to be preferably performed in a sealed container. P. Ex.                                                    
                          2002, col. 2,11. 23-27.                                                                                                                      
                F 30. Par6 426 says the semipermeable membrane separates the volatile components from the                                                              
                          contents of the container. P. Ex. 2002, col. 6,11. 21-23.                                                                                    
                F 31. Par6 426 also describes the use of a sorbent to absorb and separate the volatile components                                                      
                          released by the application of microwaves. P. Ex. 2002, col. 4,11. 37-40.                                                                    
                F 32. The particular sorbent is said to be dependent upon the particular volatile material of interest.                                                
                          P. Ex. 2002, col. 8,11. 25-M                                                                                                                 
                F 3' ). Par6 426 notes that using the microwave techniques of the invention, volatile components                                                       
                          for a variety of uses may be generated more easily with greater efficiency while allowing for                                                
                          less error and contamination. P. Ex. 2002, col. 2,11. 13-22.                                                                                 
                F 14. Example 2 of Par6 426 states, in relevant part:                                                                                                  
                                   Fresh sage, of 80% moisture content, obtained from Saint-Jean-sur-Richelieu,                                                        
                                   Quebec, Canada, was chopped coarsely into pieces and subjected to                                                                   
                                   conventional purge and trap analysis as well as to conventional headspace                                                           
                                   analysis. A portion of the same material was inserted into a container. The                                                         
                                   container was sealed by a cover through which an orifice had been made. A                                                           
                                   commercially available sorbent, in an appropriate container, was fitted from                                                        
                                   the inside of the container to the orifice thus creating an hermetic seal. The                                                      
                                   container and its contents were then treated by exposure to microwave                                                               
                                   radiation for 90 seconds so as to severely disrupt the equilibrium that existed                                                     
                                   between the solid plant material and the gases around it. The sorbent was then                                                      
                                   eluted and the eluate analyzed by gas chromatography. The results of the                                                            

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