Appeal 2007-0532
Application 10/828,316
and cellular material taken from a group consisting of living cells, cell
elements such as red blood cells, white blood cells, platelets, blood plasma,
pluripotential cells, osteoblasts, osteoclasts, and fibroblasts, epithelial cells,
and endothelial cells present at a concentration of 105 to 108 per cc of the
carrier, said hydrogel component having a molecular weight ranging from
ten thousand to three hundred thousand Daltons with a stable viscosity and
said composition having a pH ranging from about 6.8 to about 7.4[.]
26. A sterile formable bone composition as claimed in claim 23
wherein said bone particles are allograft cortical bone ranging from 100
microns to 850 microns in size at a concentration ranging from 20% to 35%
by weight of the composition.
Claim 21 is directed to a formable composition comprising
demineralized bone particles (5-50% w/w) in a viscous, phosphate buffered
aqueous carrier. The carrier contains either chitosan or sodium alginate (5-
20% by weight of the carrier) with a molecular weight of 10,000 to 300,000
Daltons and provides a stable viscosity at 22° C to 37° C. The composition
also has a pH in the range of 6.8 to 7.4 and comprises at least one of
“transforming growth factor (TGF-beta), insulin growth factor (IGF-1),
plat[e]let derived growth factor (PDGF), vascular endothelial growth factor
(VEGF), fibroblast growth factor (FGF) (numbers 1-23), osteopontin,
growth hormones such as somatotropin cellular attractants and attachment
agents.”
Claim 23 is directed to a similar composition but requires chitosan as
the hydrogel, does not require a growth factor, and requires a “cellular
material taken from a group consisting of living cells, cell elements such as
red blood cells, white blood cells, platelets, blood plasma, pluripotential
cells, osteoblasts, osteoclasts, and fibroblasts, epithelial cells, and
3
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