Ex Parte Gertzman et al - Page 10

                 Appeal 2007-0532                                                                                        
                 Application 10/828,316                                                                                  

                 elements recited in the instant claims, and that the formable composition is                            
                 then further treated to make a load-bearing implant.  The fact that Boyce                               
                 subjects the disclosed formable composition to further treatment, however,                              
                 does not prevent the disclosure of that composition from making the instant                             
                 claims unpatentable under 35 U.S.C. § 103.                                                              
                        Appellants also argue that Boyce’s working examples do not teach                                 
                 many of the limitations of the instant claims (Br. 7, 16) but that is irrelevant                        
                 to an inquiry into obviousness.  “[I]n a section 103 inquiry, ‘the fact that a                          
                 specific [embodiment] is taught to be preferred is not controlling, since all                           
                 disclosures of the prior art, including unpreferred embodiments, must be                                
                 considered.’”  Merck & Co.  v. Biocraft Labs. Inc., 874 F.2d 804, 807, 10                               
                 USPQ2d 1843, 1846 (Fed. Cir. 1989).                                                                     
                        Appellants argue that neither Sander nor Breitbart disclose all of the                           
                 limitations of the instant claims (Br. 8-12, 17-21) but the rejection is based                          
                 on the teachings of the combined references.  “Non-obviousness cannot be                                
                 established by attacking references individually where the rejection is based                           
                 upon the teachings of a combination of references.”  In re Merck & Co., 800                             
                 F.2d 1091, 1097, 231 USPQ 375, 380 (Fed. Cir. 1986).                                                    
                        Appellants also argue that “none of the cited references disclose the                            
                 additives of cells at a concentration of 105 – 108 per cc of carrier or a specific                      
                 amount of growth factor added to 10cc of carrier” (Br. 12, 21).                                         
                        This argument is irrelevant to claim 21, which requires no particular                            
                 concentration of growth factor, and it is unclear to what extent it has                                 
                 application to claim 23.  Claim 23 requires a “cellular material taken from a                           
                 group consisting of living cells, cell elements such as red blood cells, white                          


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