Ex Parte Gertzman et al - Page 9

                 Appeal 2007-0532                                                                                        
                 Application 10/828,316                                                                                  

                 position that “the molecular weight of the instant application is within the                            
                 matrix molecular weight used by [Sander] and Boyce” (Answer 12).                                        
                        The references also do not expressly disclose the pH range recited in                            
                 the claims, nor does Boyce characterize the viscosity of the slurry or paste                            
                 composition at 22° C and 37° C.  Again, however, Appellants do not argue                                
                 that either of these limitations distinguishes the claimed composition from                             
                 the one suggested by the cited references.                                                              
                        We also agree that the cited references would have suggested the                                 
                 composition of claim 26, which adds to claim 23 the limitation that the bone                            
                 particles have a size range of 100 to 850 microns (i.e., 0.1 to 0.85 mm) and a                          
                 concentration of 20-35% of the composition.  Boyce teaches a composition                                
                 having 5-100% bone particles and therefore teaches a concentration range                                
                 that overlaps the one recited in claim 26.  With respect to the particle size                           
                 range, Boyce teaches that the “powdered bone particles can range in average                             
                 particle size from about 0.05 to about 1.2 cm” (col. 4, ll. 56-58), i.e., 0.5 to                        
                 12 mm.  Thus, the range of particle sizes taught by Boyce also overlaps the                             
                 size range recited in claim 26.  “[W]here there is a range disclosed in the                             
                 prior art, and the claimed invention falls within that range, there is a                                
                 presumption of obviousness.”  Iron Grip Barbell Co., Inc. v. USA Sports,                                
                 Inc., 392 F.3d 1317, 1322, 73 USPQ2d 1225, 1228 (Fed. Cir. 2004).                                       
                        Appellants argue that Boyce teaches a “shaped hardened load bearing                              
                 osteoimplant bone structure formed of compressed bone particles and not a                               
                 . . . formable putty composition” (Br. 5, 14).                                                          
                        This argument is not persuasive.  Boyce teaches that a composition                               
                 having the consistency of a slurry or putty is formed, comprising all of the                            


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