Ex Parte PLASSE - Page 7

                Appeal No. 94-2477                                                                                                              
                Application 07/893,554                                                                                                          

                                 Noyes describes Table 3 at page 644 as follows:                                                                
                         The numbers of patients reporting various side effects are shown in Table 3.  In addition                              
                         to sedation, dizziness, blurred vision, ataxia, and slurred speech appeared to be dose-                                
                         limiting effects.  Negrete has defined severe marijuana intoxication as a mild delirium                                
                         consisting of impaired sensorium, disorientation, slurred speech, and ataxia.  According to                            
                         this author’s classification, approximately a third of patients became severely intoxicated                            
                         following 20 mg of THC.  Three patients were similarly effected by the 10 mg dose.                                     
                         Increased appetite, which was frequently reported after 10 mg of THC, was less                                         
                         commonly described following 20 mg.  This effect may have been obscured by other                                       
                         manifestations of the larger dose. [Footnote omitted.]                                                                 


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