Appeal No. 94-3012
Application 07/851,853
The references relied on by the examiner are:
Zee-Cheng et al. (Zee-Cheng) (I) 3,912,740 Oct. 14, 1975
Zee-Cheng et al. (Zee-Cheng) (II) 4,014,885 Mar. 29, 1977
Messmer et al. (Messmer), “Fagaronine, a New Tumor Inhibitor
Isolated from Fagara zanthoxyloides Lam. (Rutaceae),” Vol. 61,
No. 11, pp. 1858-1859, (Nov. 1972)
Hanaoka et al. (Hanaoka), “Synthesis of Fagaridine, A Phenolic
Benzo[c]phenanthridine Alkaloid,” Chem. Pharm. Bull., Vol. 33,
No. 4, pp. 1763-1765 (1985).
Ishii et al. (Ishii) (I), “Studies on the Chemical Constituents
of Rutaceous Plants. LX Development of a Versatile Method for
Syntheses of the Antitumor Benzo[c]phenanthridine Alkaloids.(9).
Efficient Syntheses and Antitumor Activities of Nitidine and
Related Nonphenolic Benzo[c]phenanthridine Alkaloids,” Chem.
Pharm. Bull, Vol. 33, No. 10, pp. 4139-4151 (1985).
Ishii et al. (Ishii) (II), Chemical Abstracts, Vol. 107, No. 21,
pp. 799-800, Abstract No. 198705c (1987).
Kessar et al. (Kessar), “Benzyne Cyclization Route to
Benzo[c]phenanthridine Alkaloids. Synthesis of Chelerythrine,
Decarine, and Nitidine,” J. Org. Chem., Vol. 53, pp. 1708-1712,
(1988).
Claims 4, 5, 9, 10, 13, 14, 16 through 18 and 26 through 28
stand rejected under 35 U.S.C. § 103 as being unpatentable over
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