Appeal No. 94-4393
Application 07/692,921
REMAND TO THE EXAMINER
We remand this application for the examiner to consider the following issues and
take appropriate action.
Representative Claims
Claims 1, 4, 7, and 9 are illustrative of the subject matter under review in this appeal
and read as follows:
1. A method for depleting heparin of a heparin subspecies with high or low
affinity for transforming growth factor-beta which comprises:
providing a polypeptide containing a heparin-binding region of TGF-$;
immobilizing the polypeptide on an insoluble substrate;
contacting the immobilized polypeptide with heparin for a sufficient time to allow
binding; and
collecting the unbound heparin.
4. A method according to Claim 1 which further comprises purifying the
unbound heparin.
7. A purified Heparin subspecies having anticoagulant activity and which does
not bind to transforming growth factor $.
9. A method for purifying heparin fractions with high or low affinity for
transforming growth factor-beta which comprises:
2
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Last modified: November 3, 2007