Ex parte MELLO et al. - Page 5

                 Appeal No. 95-2655                                                                                                                     
                 Application 07/912,029                                                                                                                 

                          The physiological visco-elastic formulation of appealed                                                                       
                 claim 1 contains 0.1 to about 5% hyaluronate salt in a                                                                                 
                 balanced salt solution containing 2.6 to 3.9 millimoles (mM)                                                                           
                 of calcium ions and 1.2 to 1.8 mM of magnesium ions, with the                                                                          
                 formulation being free of phosphates.                                                                                                  
                          The Abstract discloses a formulation of 1 to 2%                                                                               
                 hyaluronate and/or hydroxypropylmethyl cellulose (HPMC) in a                                                                           
                 balanced salt solution containing calcium and magnesium ions.                                                                          
                 The formulation is free of phosphates and useful for                                                                                   
                 preventing corneal damage in eye operations.  Similarly to                                                                             
                 appellants’ formulation, the Abstract teaches that the                                                                                 
                 preferred buffer is one whose composition resembles that of                                                                            
                 the aqueous humor.  The Abstract discloses one specific                                                                                
                 example to a balanced salt solution containing magnesium ions                                                                          
                 and calcium ions with HPMC.                                                                                                            
                          Appellants cite Gasser in the brief (page 6) as prior art                                                                     
                 that shows the composition of the human aqueous humor is well                                                                          
                 known .  Gasser also discloses the relatively similar BSS and5                                                                                                                             

                          5"Effects of Intraocular Irrigating Solutions on the                                                                          
                 Corneal Endothelium After in Vivo Anterior Chamber                                                                                     

Page:  Previous  1  2  3  4  5  6  7  8  9  10  11  12  13  14  Next 

Last modified: November 3, 2007