Ex parte COOPER et al. - Page 9




          And Appeal No 94-1146                                                       
          Application 07/746,050                                                      
               Since methyl is a next higher homologue of ethyl,                      
               the claimed compounds are obvious variants of the                      
               compound claimed in the copending application.                         
          The examiner’s finding is clearly erroneous.  The difference                
          between the claimed compounds and the compound of the                       
          copending application lies not only at the 5, 9, or 13                      
          position of macrolactam aglycone ring of the claimed                        
          antibiotics but also in the difference between the 3-amino-                 
          3,6-dideoxymannopyranose isomer which is attached to C-6 of                 
          the macrolactam aglycone ring of the compound claimed in this               
          application and the 3-amino-                                                
          3,6-dideoxytalopyranose isomer which is attached to C-6 of the              
          macrolactam aglycone ring of the compound claimed in the                    
          copending application.  In addition to the previously stated                
          reasons for reversing the examiner’s rejection of Claims 1-12               
          under 35 U.S.C. § 103 in view of the teaching of Japan 59-                  
          18035, the examiner also has not established that a disclosure              
          of one isomer would have enabled persons skilled in the art to              
          make and use the other.                                                     
          4.   Conclusions                                                            
               We reverse all the examiner’s rejections.                              
                                      REVERSED                                        


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