Ex parte LAJOIE et al. - Page 3




          Appeal No. 94-1911                                                          
          Application 07/662,735                                                      
                    11. The method of microbiologically degrading                     
               organic material in a mixed microbiologically competitive              
               environment which comprises introducing to said environment            
               a recombinantly modified microorganism in the presence                 
               of at least one substance not normally utilized by micro-              
               organisms indigenous to said environment but utilized                  
               as a growth substrate by said recombinantly modified micro-            
               organism, said recombinantly modified microorganism having             
               been genetically modified to express upon utilization of               
               said growth substrate at least one enzyme operable in the              
               degradation of said organic material.                                  
                    6.   The method according to claim 11 wherein said                
               substrate is a surfactant.                                             
          2.   Discussion                                                             
               In re Oetiker, 977 F.2d 1443, 24 USPQ2d 1443 (Fed. Cir.                
          1992) instructs at 1445, 24 USPQ2d at 1444:                                 
               [T]he examiner bears the initial burden, on review of                  
               the prior art or on any other ground, of presenting a                  
               prima facie case of unpatentability.                                   
          This burden should be no revelation to examiners.  In re Fine,              
          837 F.2d 1071, 5 USPQ2d 1596 (Fed. Cir. 1988) teaches at 1074,              
          5 USPQ2d at 1598:                                                           
               The PTO has the burden under section 103 to establish a                
               prima facie case of obviousness. . . . It can satisfy this             
               burden only by showing some objective teaching in the                  
               prior art or that knowledge generally available to one                 
               of ordinary skill in the art would lead that individual                
               to combine the relevant teachings of the references.                   
          Moreover, “The first paragraph of § 112 requires nothing more               
          than objective enablement. . . . How such a teaching is set                 
          forth, either by the use of illustrative examples or by broad               


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