Ex parte CUMMINS - Page 9




          Appeal No. 94-2097                                                          
          Application 07/875,630                                                      


               We shall not pass on the merits of the examiner's prima                
          facie case of obviousness.  We shall assume arguendo, without               
          deciding, that the claimed method would have been prima facie               
          obvious over Hasegawa or Tompkins.  Nevertheless, in our                    
          judgment, comparative data in appellant's specification serves              
          to rebut any such prima facie case.  See particularly EXAMPLES              
          3, 4, and 5 in the specification, showing that low oral doses               
          of human alpha interferon provide unexpectedly superior                     
          antiviral properties on treating cattle.  EXAMPLES 3, 4, and 5              
          adequately represent the narrow low dose range set forth in                 
          the claims (about 0.1 to about 1.5 IU/lb of body weight per                 
          dose per day), and show that low doses of interferon provide                
          unexpectedly superior antiviral properties compared with                    
          higher doses outside the claimed range.  On the strength of                 
          this specification evidence, we reverse the § 103 rejections                
          based on Hasegawa or Tompkins.                                              
                                     OTHER ISSUE                                      
               One further point warrants attention.  In the Examiner's               
          Answer, paragraph bridging pages 2 and 3, the examiner states               
          as follows:                                                                 



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