Appeal No. 94-2592
Application 07/707,265
This is an appeal from the final decision of the Primary
Examiner rejecting claims 31 through 33. Claims 20 through 26
and 34 are also pending, but have been withdrawn by the
examiner under 37 CFR § 1.142(b).
Claim 31 is illustrative of the subject matter on appeal
and reads as follows:
31. A process for the preparation of an eglin compound
having the following amino acid sequence:
N-acetyl-Thr-Glu-Phe-Gly-Ser-Glu-Leu-Lys-Ser-Phe-Pro-Glu-Val-
Val-Gly-Lys-Thr-Val-Asp-Gln-Ala-Arg-Glu-Tyr-Phe-Thr-Leu-His-
Tyr
-Pro-Gln-Tyr-Asp-Val-W-Phe-Leu-Pro-Glu-Gly-Ser-Pro-Val-Thr-
Leu-
Asp-Leu-Arg-Tyr-Asn-Arg-Val-Arg-Val-Phe-Tyr-Asn-Pro-Gly-Thr-
Asn
-Val-Val-Asn-His-Val-Pro-His-Val-Gly
(Formula XIV’)
in which W is Tyr or His, said process comprising:
a) transforming host cells of Escherichia coli or
Saccharomyces cerevisiae with an expression vector, said
expression vector comprising a promoter of host cell origin
and
a DNA sequence coding for said eglin compound, wherein said
DNA sequence is directly and operably linked to and in proper
reading frame relative to said promoter, in a liquid medium
containing assimilable sources of carbon and nitrogen,
2
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Last modified: November 3, 2007