Appeal No. 94-2592
Application 07/707,265
The references relied on by the examiner are:
Riggs 4,431,739 Feb. 14, 1984
(filed Jul. 30, 1982)
DeBoer 4,551,433 Nov. 5, 1985
(filed Jan. 11, 1982)
Seemüller et al. 4,636,489 Jan. 13, 1987
(Seemüller ‘87) (filed Jul. 6, 1984)
Seemüller et al. (Seemüller ‘80), “Structure of the Elastase-
Cathepsin G Inhibitor of the Leech Hirudo medicinalis,”
Z. Physiol. Chem., Vol. 361, pp. 1841-1846 (December, 1980).
Miyanohara et al. (Miyanohara), “Expression of Hepatitis B
Surface Antigen Gene in Yeast,” Proc. Natl. Acad. Sci., USA,
Vol. 80, pp. 1-5 (January, 1983).
Knecht et al. (Knecht), “Sequence Determination of Eglin C
Using Combined Microtechniques of Amino Acid Analysis, Peptide
Isolation, and Automatic Edman Degradation,” Analytical
Biochemistry, Vol. 130, pp. 65-71 (1983).
The references relied on by the appellants are:
Waller et al. (Waller), “Selective Acetylation of the Terminal
Amino Group of Corticotrophin,” Biochem. Journal, Vol. 75, pp.
320-328 (1960).
Brown et al. (Brown), “Evidence that Approximately Eighty per
Cent of the Soluble Proteins from Ehrlich Ascites Cells are
N"-Acetylated,” The Journal of Biological Chemistry, Vol. 251,
No. 4, pp. 1009-1014 (February, 1976).
Roth et al. (Roth), “Acetylation of the NH2-terminal Serine of
Prostaglandin Synthetase by Aspirin,” The Journal of
Biological Chemistry, Vol. 253, No. 11, pp. 3782-3784 (June,
1976).
Smyth et al. (Smyth), “Endorphins are Stored in Biologically
Active and Inactive Forms: Isolation of "-N-acetyl Peptides,”
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