Ex parte BAKER et al. - Page 6




          Appeal No. 95-1682                                                          
          Application 07/853,459                                                      



                    On pages 8-10 of the brief, pages 3-4 of the reply                
          brief and pages 2 and 3 of the supplemental reply brief,                    
          Appellants argue that the Examiner’s rejection of claim 8 as                
          being unpatentable is improper because Maizel and Pustell                   
          cannot handle many more than 10,000 bases.  We note that                    
          Appellants' claim 8 recites "the means for making the dotplot               
          is able to make a dotplot wherein each sequence of tokens                   
          being compared contains at least n tokens, where n >> 10,000."              
                    On page 2 of the supplemental reply brief, Appel-                 
          lants state that they do not doubt that the Maizel program can              
          handle sequences of more than 10,000 bases.  However, the                   
          Appellants argue that Maizel and Pustell cannot in fact handle              
          many more than 10,000 bases as recited in Appellants' claim 8.              
                    We find that the Examiner has established a prima                 
          facie case.  Maizel teaches on page 7665 that these programs                
          enable the approach to be used with sequences of more than                  
          10,000 bases.  Appellants have not shown how the claim lan-                 
          guage of "n >> 10,000" distinguishes over the teachings of                  
          Maizel.  Furthermore, Appellants have not shown that the                    
          Maizel programs are not enabled to be used with sequences of                

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