Appeal No. 95-3911
Application No. 08/189,124
We have carefully considered the entire record before us,
and we will reverse the obviousness rejections of claims 1
through 4 and 6 through 8.
Makino discloses a fluorescent microscope system (Figures
6 and 7) that uses fluorescence to determine a calcium
concentration in a sample cell 10. A fluorescent probe (e.g.,
fura-2) is administered to the sample cell 10, and the sample
cell 10 then emits fluorescence light by radiation of the
excitation light from illumination apparatus 1 (column 8,
lines 7 through 19). The fluorescence light is analyzed to
determine the calcium concentration (column 8, lines 20
through 23; column 10, lines 32 through 34). A printer 17
produces a hard copy of color image data, a computer 15 stores
the color image data, and monitor 16 provides a view of the
color image data (column 10, lines 27 through 35).
Modell discloses a system and method for sensing a target
substance within a tumor 86 (Figure 2). A photodynamic
sensitizer (e.g., a dye such as hematoporphin derivative
(HPD)) is injected into the area where the tumor is located.
When the area is irradiated with light, the higher
concentrations of photodynamic sensitizer within the malignant
4
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