Ex parte RHODES et al. - Page 3




             Appeal No. 95-4824                                                                                   
             Application 07/966,163                                                                               


                                                    OPINION                                                       
                    We have carefully considered all of the arguments advanced                                    
             by appellants and the examiner and agree with appellants that the                                    
             aforementioned rejections are not well founded.  Accordingly,                                        
             these rejections will be reversed.                                                                   
                    Coveney discloses bismuth-containing pharmaceutical                                           
             compositions which are suitable for oral administration and which                                    
             coat the gastrointestinal tract (col. 1, lines 59-63).  The                                          
             compositions include from about 0.1% to about 50% of a                                               
             pharmaceutically-acceptable bismuth-containing agent, from about                                     
             0.1% to about 25% of a pharmaceutically acceptable non-ionic                                         
             cellulose ether polymer, and from about 0.1% to about 25% of                                         
             magnesium aluminum silicate, wherein the ratio of bismuth to non-                                    
             ionic cellulose ether polymer is greater than about 1.5:1 (col.                                      
             1, line 63 - col. 2, line 3).  The compositions are useful for                                       
             treating or preventing disturbances of the gastrointestinal                                          
             tract, such as diarrhea, nausea, heartburn, indigestion, upset                                       
             stomach, gastritis and ulcers (col. 2, lines 6-8; col. 6, lines                                      
             10-30).                                                                                              






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