BARKER V. ELSON et al. - Page 32




          Interference No. 103,146                                                    



          See Merck & Co. v. Danbury Pharmacal, Inc., 873 F.2d 1418,                  
          1422,    10 USPQ2d 1682, 1686 (Fed. Cir. 1989).  Rather, this               
          element of inequitable conduct must generally be inferred from              
          the facts and circumstances surrounding the  applicants'                    
          overall conduct.  See Paragon Podiatry Lab., Inc. v. KLM Lab.,              
          Inc., 984 F.2d 1182, 1190, 25 USPQ2d 1561, 1567 (Fed. Cir.                  
          1993); Merck, 873 F.2d at 1422, 10 USPQ2d at 1686.  Moreover,               
          the Federal Circuit has                                                     
          recognized that the more material the omission, the less the                
          degree of intent that must be shown to reach a conclusion of                
          inequitable conduct.  See Critikon, Inc. v. Becton Dickinson                
          Vascular Access, Inc., 120 F.3d 1253, 1256, 43 USPQ2d 1666,                 
          1668 (Fed. Cir. 1997), cert. denied, 118 S.Ct. 1511 (1998) and              
          cert. denied, 118 S.Ct. 1510 (1998); Akzo N.V. v. U.S. Int'l                
          Trade Comm'n, 808 F.2d 1471, 1481-82, 1 USPQ2d 1241, 1247                   
          (Fed. Cir. 1986), cert. denied, 482 U.S. 909 (1987).                        
                    No single factor or combination of factors                        
                    can be said always to require an inference                        
                    of intent to mislead; yet a patentee facing                       
                    a high level of materiality and clear proof                       
                    that it knew or should have known of that                         
                    materiality, can expect to find it                                


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