Ex parte LONIAL et al. - Page 3




              Appeal No. 95-0420                                                                                        
              Application 07/959,509                                                                                    


              the supplemental Reply Brief, and the Examiner's Answer and supplemental Answer, we                       
              reverse the examiner's rejection under 35 USC § 103.                                                      
                                                    DISCUSSION                                                          
                     First, in presenting their case before the Board, Appellants group and argue claim                 
              17 separately.  See the main Brief, pages 3, 12 and 13.  The examiner, however, does not                  
              focus separately on claim 17.  The examiner does not explain how or why a person having                   
              ordinary skill in the art, armed with disclosures of Selden and Tsang, would have arrived at              

              the plasmid defined in this claim.  Therefore, the examiner has not established a prima                   

              facie case of unpatentability of clam 17, and the rejection of this claim on prior art grounds            

              is reversed.                                                                                              
                     Second, in claims 1 through 16, Appellants recite a human cell line which has been                 
              stably transformed by a recombinant vector.  Manifestly, the combined disclosures of                      
              Selden and Tsang are insufficient to support a conclusion of obviousness of claims                        
              containing that limitation.  As acknowledged by the examiner in the supplemental Answer,                  
              page 2, second paragraph, "[t]he rejection does not supply a reference teaching stably                    
              transfected cells". (emphasis added).  Where, as here, the combined disclosures of                        
              Selden and Tsang do not reach the claimed subject matter as a whole,                                      


              including the requirement of a human cell line that has been stably transformed by a                      


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