Ex parte LONIAL et al. - Page 4




              Appeal No. 95-0420                                                                                        
              Application 07/959,509                                                                                    


              recombinant vector, the stated rejection under 35 USC § 103 cannot stand.  The rejection                  
              of claims 1 through 16 under 35 USC § 103 as unpatentable over the combined                               
              disclosures of Selden and Tsang is reversed.                                                              
                     We are mindful that the examiner cites three new references in the Examiner's                      
                      2                                                                                                 
              Answer;   that the examiner discusses one of these references in the Examiner's Answer,                   
              page 5, and all of those references in the supplemental Answer, paragraph bridging pages                  
              2 and 3; and that the examiner further refers to an acknowledgment made in Appellants'                    
              Reply Brief (supplemental Answer, page 3, lines 1 through 4).  The new references and the                 
              acknowledgment, however, are not  included in the statement of rejection under 35 USC §                   
              103.  As stated in In re Hoch, 428 F.2d 1341, 1342 n3, 166 USPQ 406, 407 n3 (CCPA                         
              1970),                                                                                                    
                     Where a reference is relied  on to support a rejection, whether or not in a                        
                     "minor capacity," there would appear to be no excuse for not positively                            
                     including the reference in the statement of the rejection.                                         
              We shall not pass on the merits of the unstated rejection which the examiner belatedly                    
              attempts to bring  through the "back door", based on the combined disclosures of                          


              Selden, Tsang, Wurm, MacDonald, and Smith, and an acknowledgment found in                                 

                     2These new references are: (a) Wurm, "Integration, Amplification and Stability of Plasmid          
              Sequences in CHO Cell Cultures", Biologicals, Vol. 18, pp. 159-164, (1990); (b) Macdonald, "Development   
              of New Cell Lines for Animal Cell Biotechnology", Biotechnology, Vol. 10, No. 2, pp.       155-178, (1990) ;
              and (c) Smith et al., U.S. Patent No. 5,223,421  Jun. 29, 1993.                                           
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