Ex parte BONAVENTURA et al. - Page 5




          Appeal No. 95-1779                                                          
          Application 07/683,130                                                      
               contact with a liquid (e.g. an enzyme reactor).  As a                  
               result, it would have been obvious to one of ordinary                  
               skill in the art to determine the optimum manner in which              
               the enzyme of Christie is incorporated into the marine                 
               coating while maintaining the required antifouling                     
          function                                                                    
               discussed by the reference of Christie.  Whether the                   
               enzyme is physically entrapped or chemically attached                  
               would have been merely an obvious matter in design choice              
               based on considerations such as the specific enzyme to be              
               immobilized, the material of the surface to be coated,                 
               the material of the coating and/or the environment in                  
               which the surface is to be exposed.                                    
               It is apparent to this panel that the examiner’s                       
          rejection is based on impermissible hindsight.  We find no                  
          indication in the references cited by the examiner that the                 
          manner in which the enzyme of an enzymatic antifouling marine               
          coating is incorporated in the coating is a result effective                
          variable.  Moreover, we find no prior art teaching that                     
          “[w]hether the enzyme is physically entrapped or chemically                 
          attached would have been merely an obvious matter in design                 
          choice based on considerations such as the specific enzyme to               
          be immobilized, the material of the surface to be coated, the               
          material of the coating and/or the environment in which the                 
          surface is to be exposed.”  Furthermore, we find no reasonable              
          suggestion in the cited prior art which would have led persons              
          having ordinary skill in the art to chemically bond an enzyme               
          in an enzymatic antifouling marine coating to the inert matrix              
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