Appeal No. 95-1881
Application 08/032,166
examiner’s rejections of Claims 1, 2, 4, and 8 through 24, all
claims pending in this application.
Claims 1, 2, 4, and 8 through 24 stand finally rejected
(1) under 35 U.S.C. § 112, first paragraph, for noncompliance
with its description requirement; (2) under 35 U.S.C. § 112,
first paragraph, for noncompliance with its enablement
requirement; and (3) under 35 U.S.C. § 103 as being
unpatentable in view of the teaching of Montreuil et al.
(Montreuil), Carbohydrate Analysis - A Practical Approach, IRL
Press,
pp. 144-152 (1986). Representative Claim 1 reads:
1. A method for releasing an O-glycan from a
glycoconjugate which method comprises
reacting said glycoconjugate with a hydrazine
reagent,
said glycoconjugate being essentially salt-free and
essentially anhydrous and said hydrazine reagent being
essentially anhydrous, and
controlling the time and temperature conditions
under
which the glycoconjugate is subjected to the influence
of the hydrazine reagent within a range, according to
first-order kinetics, corresponding to about 55 C to O
about 75 C at 8 hours so as to release O-glycans fromO
the glycoconjugate recoverable in substantially unreduced
and intact form.
We reverse all the examiner’s rejections, essentially for
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