Appeal No. 95-2371
Application 07/771,097
Claims 1 and 14 are illustrative of the subject matter on appeal and read as follows:
1. A method for determining an analyte in a sample solution, said method
comprising: contacting said sample solution with a receptor in solution which specifically
binds to said analyte to form a precipitate; and quantitatively measuring the amount of
formation of said precipitate by a nephelometric or turbidimetric method as a
measurement of the amount of said analyte present in said sample solution; said
contacting of said sample solution with said receptor being in the presence of at least one
non-ionic polymer selected from the group consisting of a polyvinyl pyrrolidine having
molecular weight of at least 360,000 and a polyethylene glycol having a molecular weight
of at least 40,000.
14. Reagent useful in determining an analyte via a precipitation reaction,
comprising: a receptor comprising at least one antibody which specifically binds to said
analyte to form a precipitate, and at least one non-ionic polymer selected from the group
consisting of a polyvinyl pyrrolidine having a molecular weight of at least 360,000 and a
polyethylene glycol having a molecular weight of at least 40,000.
The references relied upon by the examiner are:
Cole 5,102,788 Apr. 7, 1992
(Filed Apr. 28, 1989)
Chichibu et al. (Chichibu)
(Japanese Kokai) 58-2660 Jun. 30, 19812
Hellsing, Automated Immunoanalysis, Chapter 3: Enhancing Effects of Nonionic Polymers
on Immunochemical Reactions, pp. 67-112 (1977)
2It appears that the examiner’s consideration of this reference has been limited to
an English language abstract thereof. We have obtained a full text translation of this
Japanese language document and have based our consideration of the examiner’s
rejection on the full text translation.
2
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