Appeal No. 95-2688
Application No. 07/845,560
derivatives (retinoids) for the treatment and prevention of disorders of epithelial tissues.
Representative composition claim 1 is reproduced below:
1. A composition for the treatment of epithelial damage in a mammal comprising a
pharmacologically active retinoid and pharmacologically active DHEA wherein the
combination is effective in preventing or reversing damage to the epithelium due to
environmental oxidative agents and wherein the proportion of retinoid and DHEA is
sufficient to overcome the undesirable side effects of each composition when used alone.
The references of record relied upon by the examiner are:
Orentreich (Orentreich '556) 4,496,556 Jan. 29, 1985
Orentreich (Orentreich '129) 4,542,129 Sep. 17, 1985
Kligman et al. (Kligman) 4,889,847 Dec. 26, 1989
References of record relied upon by the appellant are:
Greenspan (Editor), "Disorders of Adrenal Cortex," in
Review of Endocrinology , Lange, 818, 819 and 275, undated publication.
Martin Bohl et al (Editor), "Molecular Structure and Biological Activity of Steroids" 2, 3, 4,
16, 17 (Boca Raton, FL, CRC Press, 1992).
Louis S. Goodman et al., Chap. 60 "Adrenocortical Steroids: "Inhibitors of Synthesis," in
60 Goodman and Gilman's The Pharmacological Basis of Therapeutics", 554-557 (8th
ed., New York, Pergamon Press, 1990).
Emil L. Smith et al., PRINCIPLES OF BIOCHEMISTRY: Mammalian Biochemistry 498-567
(7th ed., New York, McGraw-Hill Book Company, undated publication).
Mary May et al.(May), "PROTECTION FROM GLUCOCORTICOID INDUCED THYMIC
INVOLUTION BY DEHYDROEPIANDROSTERONE," 46 Life Sciences, 1627-1631
(1990).
Raymond A. Daynes et al., "Regulation of murine lymphokine production in vivo II.
Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T
cells*," 20 Eur. I. Immunol. 793-802 (1990).
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