Appeal No. 95-3117
Application 08/096,207
This is an appeal under 35 U.S.C. § 134 of an examiner’s
rejection of Claims 23, 24, 28, 29, 34-37, 43, and 46. The
examiner allowed Claims 47-53 (Paper No. 26), the only
remaining claims in this application.
Introduction
Claims 23, 24, 28, 29, 34-37, 43, and 46 stand rejected
under 35 U.S.C. § 103 as being unpatentable in view of the
combined teachings of Yu et al. (Yu I), “Carbamate Analogues
of (-)-Physostigmine: In Vitro Inhibition of Acetyl- and
Butyrylcholinesterase,” FEBS Letters, Vol. 234, No. 1, pp.
127-130 (July 1988); Glamkowski et al. (Glamkowski), U.S.
5,081,117, patented January 14, 1992, filed November 3, 1989,
and Yu et al. (Yu II), “Synthesis and Anticholinesterase
Activity of (-)-N -Norphysostigmine, (-)-Eseramine, and Other1
N(1)-Substituted Analogues of (-)-Physostigmine,” J. Med.
Chem., Vol. 31, No. 12, pp. 2297-2300 (1988). Claims 23, 24,
28, 29, 34-37, 43, and 46 also stand rejected under 35 U.S.C.
§ 103 as being unpatentable in view of the combined teachings
of Yu I, Glamkowski, Yu II, and Albuquerque et al.
(Albuquerque), “Multiple Actions of Anticholinesterase Agents
on Chemosensitive Synapses: Molecular Basis for Prophylaxis
and Treatment of Organophosphate
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