Ex parte COOK - Page 2




          Appeal No. 95-4435                                                            
          Application No. 07/833,146                                                    


          remaining in the application, stand withdrawn from further                    
          consideration by the examiner as directed to a non-elected                    
          invention.                                                                    
               Claim 22, which is illustrative of the subject matter on                 
          appeal, reads as follows:                                                     
          22. An oligonucleotide wherein at least one nucleotide unit                   
          of said olignonucleotide [sic, oligonucleotide] includes a                    
          phosphate moiety having the following structural formula:                     
                         *                                                              
          O                                                                             
                         *                                                              
          O =  P - O -                                                                  
                         *                                                              
          (Y)n                                                                          
                         *                                                              
                                     -      +                                           
                         A  - CH - M , wherein n is O or 1; and                         
          Y is:                                                                         
               (Z) -R , wherein R  is a hydrocarbon, p is O or 1, and Z isp  1           1                                                      
          oxygen, sulfur, or NR , wherein R  is hydrogen or a2           2                                           
          hydrocarbon; M  is:+                                                              
                         R3                                                             
                         *                                                              
                         N  - R           +    4                                        
                         *                                                              
                         R5                                                             
               wherein each of R , R , and R  is hydrogen or a3  4       5                                           
          hydrocarbon, and each of R , R , and R  may be the same or3  4       5                                       
          different, and A- is selected from the group consisting of                    
                  -        2-                                                          
          COO-, SO , and PO .3        3                                                           
               As stated in the Examiner's Answer, page 2, sections (7)                 
          and (8), the examiner does not rely on any prior art of                       
                                          -2-                                           




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