Ex parte COOK - Page 4




          Appeal No. 95-4435                                                          
          Application No. 07/833,146                                                  


               The oligonucleotides may be used in vitro or in                        
               vivo for modifying the phenotype of cells, or for                      
               limiting the proliferation of pathogens such as                        
               viruses, bacteria, protists, Mycoplasma species,                       
               Chlamydia or the like, or for inducing morbidity in                    
               neoplastic cells or specific classes of normal                         
               cells.                                                                 
          Manifestly, the specification describes in vitro utilities,                 
          contrary to the examiner's characterization.  Where, as here,               
          a legal conclusion of non-enablement is based on clearly                    
          erroneous fact-finding, the legal conclusion cannot stand.                  
               Furthermore, the Examiner's Answer is internally                       
          inconsistent and procedurally flawed.  In the Answer, page 2,               
          sections (7) and (8), the examiner states that no prior art of              
          record is relied on, nor is any new prior art cited or relied               
          on in rejecting the appealed claims.  Nevertheless, in the                  
          Examiner's Answer, paragraph bridging pages 6 and 7, and in                 
          the first full paragraph of page 7, the examiner makes                      
          reference to the "Ulhmann et al." publication.  In the                      
          Examiner's Answer, the examiner does not provide a citation                 
          for "Ulhmann et al.," nor is it clear from the record just                  
          what this publication is.  Apparently, the examiner does rely               
          on it.  This, in and of itself, constitutes reversible error.               



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