Ex parte CROWELL et al. - Page 6




          Appeal No. 1996-0721                                                          
          Application No. 08/036,640                                                    


          formula described in the Korger reference.  Nor has the                       
          examiner explained why the above disclosures of McLamore and                  
          Lucius would have led one of ordinary skill in the art to                     
          employ the claimed halophenyl radical in the general formula                  
          described in the Korger reference.                                            
               Even were we to read R’ in McLamore as including all of                  
          the species described at page 2 therein (which we do not) as                  
          appears to be suggested by the examiner (Answer, page 4), we                  
          determine that McLamore would not have suggested the                          
          employment of the claimed halophenyl radical as R  of the                     
                                                            1                           
          general formula described in the Korger reference.                            
          Specifically, the Ruschig reference relied on by appellants,                  
          like Korger, teaches preference for (CH) C H  as R  of then 6 5    1                           
          general formula described in Korger for lowering blood sugar.                 
          See page 5, together with Brief, page 6.  In addition, the                    
          Ruschig reference teaches that the use of a substituted or                    
          unsubstituted phenyl radical as R  of the general formula                     
                                            1                                           
          described in Korger would render the formula ineffective for                  
          lowering blood sugar and render the formula extremely toxic                   
          for humans.  See Brief, page 6, together with Ruschig, pages 4                
          and 5.  Thus, we agree with appellants that one of ordinary                   
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