Ex parte VELLUTATO - Page 5


                     Appeal No. 1996-1801                                                                                                                                              
                     Application 08/142,049                                                                                                                                            

                     the prior art and its relationship to the applicant’s invention.”); In re Keller, 642 F.2d 413, 425, 208                                                          
                     USPQ 871, 881 (CCPA 1981)(“The test for obviousness is not whether the features of a secondary                                                                    
                     reference may be bodily incorporated into the structure of the primary reference; nor is it that the                                                              
                     claimed invention must be expressly suggested in any one or all of the references. Rather, the test is                                                            
                     what the combined teachings of the references would have suggested to those of ordinary skill in the                                                              
                     art.”).                                                                                                                                                           
                                We reach the same result with respect to the ground of rejection of appealed claim 14, which                                                           
                     rejection is principally founded on the same combination of references.                                                                                           
                                Accordingly, since the examiner has established a prima facie case of obviousness, we have                                                             
                     again evaluated all of the evidence of obviousness and nonobviousness based on the record as a whole,                                                             
                     giving due consideration to the weight of appellant’s arguments.  See generally In re Johnson, 747                                                                
                     F.2d 1456, 1460, 223 USPQ 1260, 1263 (Fed. Cir. 1984); In re Piasecki, 745 F.2d 1468, 1472,                                                                       
                     223 USPQ 785, 788 (Fed. Cir. 1984).                                                                                                                               
                                We have carefully considered all of appellant’s arguments in the brief and agree with the                                                              
                     examiner’s response thereto set forth in the answer.  As pointed out by the examiner, and as we have                                                              
                     set forth above, it is the combined teachings of the references, and not appellant’s disclosure, which                                                            
                     provides the objective evidence that one of ordinary skill in this art would have been motivated to                                                               
                     irradiate the final package containing the biological material with the reasonable expectation of obtaining                                                       
                     the desired level of sterilization.  Gorman, supra; Keller, supra; compare generally, Fritch, 972                                                                 
                     F.2d at 1265-66, 23 USPQ2d at 1783-84.  We fail to find in the record any evidence that the claimed                                                               
                     method of sterilization provides a new or unexpected result.                                                                                                      
                                Accordingly, based on our consideration of the totality of the record before us, we have weighed                                                       
                     the evidence of obviousness found in the combined teachings of Falciani, Anthony and Bacehowski, with                                                             
                     respect to appealed claims 1, 4, 5, 8, 9, 13, 16, 17 and 19, and the combined teachings of Falciani,                                                              
                     Anthony, Bacehowski, Pomerantz and Anderson, with respect to appealed claims 14 and 15, with                                                                      
                     appellant’s countervailing evidence of and argument for nonobviousness and conclude that the claimed                                                              
                     invention encompassed by appealed claims 1,4, 5, 8, 9, 13 through 17 and 19 would have been obvious                                                               


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