Ex parte ZIOLO et al. - Page 6


                     Appeal No. 1996-3980                                                                                                                                              
                     Application 08/290,125                                                                                                                                            

                     sufficiently to have placed a person of ordinary skill in the art in possession of this composition, thus                                                         
                     anticipating claim 1 under § 102(b).  In re Spada, 911 F.2d 705, 708, 15 USPQ2d 1655, 1657 (Fed.                                                                  
                     Cir. 1990).  Indeed, as seen from Maruno Example 1 and complexes No. 2 through 7 of Maruno                                                                        
                     Table 2, Maruno Example 2 and complexes No. 15 and 18 through 21 of Maruno Table 4, and                                                                           
                     Maruno Example 3 and Maruno Table 5, the magnetic complexes disclosed by Maruno can comprise                                                                      
                     about 44 to 62 weight percent of polysaccharide carboxyalkyl ethers in which about 25 to 42 weight                                                                
                     percent of magnetic iron oxide particles of about 6 to 10 nm are dispersed, which compositions are                                                                
                     recovered as a powder by freeze drying.  One of ordinary skill in this art would have reasonably                                                                  
                     expected that the polysaccharide carboxyalkyl ethers and the magnetic iron oxide particles are chemical                                                           
                     bonded, as taught by Maruno (col. 10, lines 16-19), and that at least a portion of the ferrous chloride                                                           
                     used in the preparation of the complexes would form magnetite, that is, Fe O , as taught by Maruno                                                                
                                                                                                                                3  4                                                   
                     (col. 4, lines 15-16).  Thus, it reasonably appears that the complexes comprise at least a                                                                        
                     polysaccharide carboxyalkyl ether as “a resin” that contains “uniformly dispersed” “nanocrystalline                                                               
                     particles of Fe O ” that are “bonded” thereto, wherein the “resin” and the “nanocrystalline particles of                                                          
                                          3  4                                                                                                                                         
                     Fe O ” are present in certain weight percent such that the complexes are encompassed by claim 1.                                                                  
                         3  4                                                                                                                                                          
                                Accordingly, because the chemically bound complexes of carboxyalkyl ethers of                                                                          
                     polysaccharides and magnetic iron oxide particles reasonable appear to be identical to the magnetic                                                               
                     nanocomposite compositions of claim 1, the burden falls upon appellants to establish by effective                                                                 
                     argument and/or objective evidence that the claimed invention patentably distinguishes over this                                                                  
                     reference with respect to .  See Spada, 911 F.2d at 708-09, 15 USPQ2d at 1657-58; In re Best, 562                                                                 
                     F.2d 1252, 1254-56, 195 USPQ 430, 432-34 (CCPA 1977).  We have reassessed the patentability                                                                       
                     of the claimed invention encompassed by claim 1 based on the totality of the record, including all the                                                            
                     factual evidence of anticipation in Maruno and appellants’ arguments evidence that the reference is not                                                           
                     anticipatory, giving due consideration to the weight of appellants’ arguments.                                                                                    
                                We have carefully considered appellants’ arguments with respect to the difference in water                                                             
                     solubility and the affect on viscosity properties of aqueous mixtures between the polysaccharide                                                                  
                     carboxyalkyl ether containing magnetic complexes of Maruno and the “ion exchange resins of the                                                                    


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