Ex parte COLE et al. - Page 4




             Appeal No. 98-1486                                                                                   
             Application 08/417,628                                                                               


             been motivated to isolate them in solid form.  The record                                            
             indicates that the motivation relied upon by the examiner                                            
             comes solely from appellants' specification.  Hence, the                                             
             examiner used                                                                                        





             impermissible hindsight when rejecting the claims.  See W.L.                                         
             Gore & Associates v. Garlock, Inc., 721 F.2d 1540, 1553, 220                                         
             USPQ 303,                                                                                            
             312-13 (Fed. Cir. 1983); In re Rothermel, 276 F.2d 393, 396,                                         
             125 USPQ 328, 331 (CCPA 1960).                                                                       
                    Appellants argue that any clavulanic acid present in                                          
             Lilly’s fermentation broth would have been in solution and not                                       
             in solid or crystalline form (brief, page 23).  The examiner                                         
             has not responded to appellants’ argument, and it is not                                             
             apparent from the record why any salts of clavulanic acid                                            
             which are present in Lilly’s fermentation broth would be in                                          
             solid or crystalline form.                                                                           
                    For the above reasons, we do not sustain the examiner’s                                       


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