Appeal No. 1999-1236
Application 07/571,782
From Table 1 in Nevens, it can be seen that all patients 1 through 7 are classified
as “decompensated.” However, not all of patients 1 through 7 have all of the symptoms or
criteria used in that study to define “decompensated.” For example, patient number 5
lacks the presence of ascites, only patient number 1 has spontaneous bacterial peritonitis,
patients 5 and 6 lack hypersplenism or splenomegaly, and patients 1-4 and 6 lack
encephalopathy. From this information, it can be seen that all of the patients included in
the research study were considered as having “decompensated” liver disease; however,
not all of these patients were clinically the same in terms of the parameters used to define
“decompensated.”
In another prior art research study by Dimopoulou (made of record in Paper No.
15), patients with decompensated liver disease were also treated with interferon alfa-2b.
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