Interference No. 104,272 Paper No. 56
Lerner v. Lerner v. Winter Page 3
type of vector contains a polynucleotide sequence having a
restriction endonuclease recognition site upstream to the
translation initiation site. Restriction endonuclease is
added to cleave the polynucleotides at the recognition site
and to leave ligation compatible ends. Thereafter the
polynucleotides from the two different types of vectors are
ligated to form the coexpression vectors. In the '762
application, the coexpression vectors are synthesized by a
similar method, but the '762 process includes only a generic
step of joining the two different types of polynucleotide
sequences. There is nothing in the record to indicate that
one skilled in the art would have been motivated to select the
specific method of joining the two different polynucleotides
as claimed by the '761 application in view of the '762 claims.
Therefore the '761 claims are not anticipated or obvious in
view of the '762 claims.
In the '762 application, generic claims 32, 45, 59, 71,
80, and 90 are directed to the production of polynucleotides
and vectors containing such polynucleotides where the
polynucleotides and vectors are capable of expressing the
variable regions of the light (V ) and heavy (V ) chains ofL H
antibody molecules. Generic claims 17 and 31 of the '761
application are directed to the production of vectors
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