Appeal No. 2000-0320 Page 11
Application No. 08/480,082
hyaluronic acid and their salts. Among the ionically
crosslinkable cationic polymers that may be employed are
chitosan, cationic guar, cationic starch and polyethylene
amine.
Thompson further teaches that the polymeric material in
which the disintegration agent is encapsulated or associated
is an ionically crosslinkable polymer which may be the same as
or
different from the ionically crosslinkable matrix polymers
described above from which the medical device itself is
fabricated. Suitable materials include but are not limited to
carboxylic, sulfate, and amine functionalized polymers such as
polyacrylic acid, polymethacrylic acid, polyethylene amine,
polysaccharides such as alginic acid, pectinic acid,
carboxymethyl cellulose, hyaluronic acid, chitosan,
carboxymethyl chitosan, carboxymethyl starch, carboxymethyl
dextran, heparin sulfate, chondroitin sulfate, cationic guar,
cationic starch, and their salts. Preferred ionically
crosslinked capsule materials are alginic acid, pectinic acid,
carboxymethyl cellulose, and chitosan and their salts. Most
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