Interference No. 103,203
15
Exhibits NRE 277 and 278. Dr. Bach states that he “wrote down the correct sequence of
the mature Tissue Factor protein on document 277. And that was written on February 3,
1987, and it contains the correct nucleotide sequence and the correct amino acid
sequence for the mature Tissue Factor protein.” NR 156, lines 20-24. NRE 277 is a
handwritten document which is dated “1/23/87” and which consists of six (6) pages of
nucleotide and amino acid sequence data which are said to have been derived from Dr.
Bach’s laboratory notebook. NR 101.
Dr. Bach testifies that NRE 277 is a revised version of NRE 275. NR 101, line 25-
102, line 2. According to Dr. Bach, NRE 275 is the original 1/23/87 document (NRE 275)
which ended on page five (5) (MS&Y 07701) at amino acid 244. NR 108, lines
20-23. In our review of NRE 277, we find that in addition to containing further nucleotide
and amino acid sequence data (i.e., beyond amino acid 244), the revised version of the
1/23/87 document (i.e., NRE 277) contains numerous modifications to said sequences.
Such modifications include nucleotide and amino acid residues being crossed out and/or
written over, calculations changed, etc. For example, page 6 of NRE 277 (MS&Y 7693)
appears as follows:
15In the portion of Dr. Bach’s testimony relied upon by Nemerson et al., NRE 275 is also
explained.
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