Appeal No. 1995-4188
Application 07/860,965
the antigen-binding sites of the immobilized antibodies are
saturated with labeled antigen before the sample is introduced
into the column, such that sample antigens must displace
bound, labeled antigen from the antigen-binding sites on the
immobilized antibodies in the column. See id.
The examiner argues that “the instant claims only claim a
system with immobilized antibodies having bound labeled
antigens which are clearly taught by Maggio” (answer, page 7).
This is not a correct interpretation of the claims, which
require that the labeled antigen saturates the antigen-binding
sites of the antibody before a sample is introduced into the
immunosensor.
The examiner argues that pages 224-225 of Maggio disclose
labeled antigens which are complexed to an immobilized
antibody, and disclose subsequent dissociation of the complex
(answer,
page 7). The dissociation discussed by Maggio is dissociation
of a complex which has been formed by competition between the
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