Ex parte ANDERSON et al. - Page 4




                 Appeal No. 1996-0963                                                                                                                   
                 Application 07/947,249                                                                                                                 
                 “[t]he process disclosed in the specification requires a considerable amount of                                                        
                 experimentation.”  Examiner’s Answer, pages 7 and 8.                                                                                   
                          Ultimately, the examiner focuses on “[t]he unpredictable nature of the art [as] the                                           
                 most important factor in the instant application.”  Examiner’s Answer, pages 4 and 5.  For                                             
                 example, the examiner argues that one “can not predict the length of time necessary to                                                 
                 select herbicide resistant cell lines . . . because of the random nature of mutagenesis . . .                                          
                 [t]he length of time is important because [it] affects the ability of cultured tissues to                                              
                 regenerate fertile plants.”  Although “it is a statistical certainty that the desired mutation will                                    
                 ultimately arise,” the examiner maintains that “it is not certain that the cell culture technique                                      
                 will allow selection and isolation of cells harboring said mutation.”  Additionally, the                                               
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                 examiner relies on Reisch  to establish that “cultured maize tissue is more cytogenetically                                            
                 stable than other monocotyledons, particularly rice and oat,” thus, “it is easier to regenerate                                        
                 normal corn plants from culture than normal plants of other species.”  Examiner’s Answer,                                              
                 page 7.                                                                                                                                
                          For these reasons, the examiner concludes that “it would require undue                                                        
                 experimentation to make the claimed plants and seeds” (Examiner’s Answer, page 8).  If                                                 
                 we can summarize the basis of the examiner’s position, it is that it would require a                                                   
                 considerable amount of experimentation, over an uncertain period of time, to develop                                                   


                          2B. Reisch, “Genetic Variability in Regenerated Plants,” in Handbook of Plant Cell                                            
                 Culture, Volume 1, D.A. Evans et al, eds., Macmillan Publishing Co, New York, NY, pp.                                                  
                 748-769 (1983).                                                                                                                        
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