Ex parte SPANA et al. - Page 3




               Appeal No. 1996-2210                                                                                             
               Application 08/129,722                                                                                           



                      (2)  whether the examiner erred in rejecting claims 23 through 26 under               35                  
               U.S.C. ' 103 as unpatentable over the combined disclosures of Ausubel and Laroche.                               

                      On consideration of the record, we affirm the rejection of claims 1 through 4,       6                    
               through 17, and 22.  However, we reverse the rejection of claims 23 through 26.                                  


                                                       DISCUSSION                                                               
                      In their Appeal Brief, applicants do not argue the patentability of claims              2                 
               through 4, 6 through 17, and 22 separately from claim 1.  Accordingly, for the purposes of                       
               this appeal, we shall treat claims 2 through 4, 6 through 17, and 22 as standing or falling                      
               together with claim 1.                                                                                           
                      For the reasons succinctly stated by the examiner (Examiner=s Answer, Paper No.                           

               21, paragraph bridging pages 3 and 4), we conclude that the subject matter sought to be                          
               patented in claim 1 would have been prima facie obvious in view of Ausubel.  It would have                       
               been prima facie obvious to produce a fusion protein of a desired eukaryotic protein and                         
               glutathione-S-transferase (GST), using a baculovirus promoter in a baculovirus system, to                        
               exploit the known advantages of that system and, simultaneously, to permit easy isolation                        
               of the desired protein using glutathione-agarose beads.                                                          
                      Applicants rely on results presented in their specification, particularly page 17, lines                  

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