Appeal No. 1996-2240
Application No. 08/105,482
Claims 1 through 32 additionally stand rejected as obvious over Matson 1987 and
Seltzer.
Matson 1987 teaches that “[c]oulometric electrode series array sensors, coupled
with liquid chromatography, provide a route to multiplying the resolving power of
conventional [liquid chromatography] by factors of 10 to 50.” The reference suggests that
“[t]he use of multiple parameter assays of entire metabolic pathways is potentially a
powerful tool for unraveling mechanisms of disorders . . . and classification of neurological
diseases” and also describes “various techniques of multiple regression and algorithm
construction” as “under investigation.” See the Summary and page 908.
Seltzer discloses frequency distribution analysis of fingerprint patterns (ulner or
radical loops, arches and whorls) to distinguish between early- and late-onset primary
degenerative dementia.
The examiner argues that “[i]t would have been obvious to one of ordinary skill in the
art at the time the invention was made to use a frequency distribution as taught by
Seltzer for the classification of neurological disorders by the Matson method because one
of skill in the art would have recognized that as taught by Seltzer, the frequency
distribution would have shown distinct classifiable differences between biological
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