Appeal No. 1996-3409
Application No. 08/092,543
appellant indicates that abnormalities in neurotransmitters and related substances are
related to degenerative, neuropsychiatric and behavioral disorders, and that Liquid
Chromatography with Electrochemical Detection (LCEC) is “a common tool for the
determination of . . . metabolites in biological fluids.”
Seltzer discloses frequency distribution analysis of fingerprint patterns (ulner or
radical loops, arches and whorls) to distinguish between early- and late-onset primary
degenerative dementia.
According to the examiner, [i]t would have been obvious to one of ordinary skill in
the art at the time the invention was made to [have] used a frequency distribution as
taught by Seltzer et al. for classification of neurological diseases by the Miyagi et al.
method because one of skill in the art would have recognized that as taught by Seltzer
et al. the frequency distribution would have shown distinct classifiable differences between
biological markers of controls and individuals with the disease. It would have been
obvious to one of ordinary skill in the art to use a conventional method, such as the
electrochemical analysis taught by Applicant and Long et al., for the sample fluid analysis
in the process taught by Miyagi et al. so as to produce patterns which are representative of
the electrochemical constituents in a body fluid which Applicant admits are known to be
associated with various diseases” and “[i]t would have been
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