THE INVENTION
The invention is directed to various processes for the preparation of carbapenem
intermediates. In one aspect of the invention a decarboxylation reaction occurs. In a
second aspect, a nucleophilic reaction on a substituted Meldrum’s acid moiety results in a
ring opening to form a carboxylic acid moiety and substitution of a nucleophile on the
remaining carbonyl moiety. The invention is further illustrated by the claims appended
below.
THE CLAIMS
Claims 1 and 5 are illustrative of appellants’ invention and are reproduced below.
1. A process for making a beta methyl carbapenem intermediate of formula VI:
wherein
R is (a) hydrogen,
(b) methyl, or
(c) a hydroxy protecting group;
2
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Last modified: November 3, 2007