Ex parte KLEE et al. - Page 5




          Appeal No. 1997-1738                                                        
          Application No. 08/255,040                                                  


               We note the examiner’s position that "There is no                      
          structural difference between a generic disclosure of a column              
          and a supercritical column" (answer, page 6).  Appellants                   
          argue otherwise, that "[T]here is a structural difference                   
          between a generic disclosure of a column and a supercritical                
          fluid chromatograph" (reply brief, page 4).  In support of the              
          differences, appellants cite Lee (Milton L. Lee, Analytical                 
          Supercritical Fluid Chromatography and Extraction,                          
          Chromatography Conferences, Inc., 1990) and provide a copy of               
          Lee appended to the reply brief.                                            


               Lee’s description of a supercritical fluid chromatograph               
          portrays an apparatus capable of providing a mobile phase in a              
          column at very high pressure, "practical pressures for                      
          applications range from less than 50 atm to more than 500 atm"              
          (Lee, page 13).  Further, Lee describes other aspects unique                
          to a supercritical fluid chromatograph like "[T]he pressure-                
          controlled pumping system which is essential for pressure or                
          density programming, and the flow or pressure restrictor at                 
          the end of the column which is required to maintain                         
          supercritical pressures inside the column" (Lee, page 145).                 
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