Appeal No. 1997-1842
Application 08/068,878
2. BPH is a condition of benign enlargement of the prostate gland that occurs in
the aging male. Fabricius, page 92, lines 8 and 9.
3. Clinically, BPH manifests as bladder obstruction. A prostate adenoma
(benign tumor of glandular origin) obstructs urinary flow by static and dynamic
components. Static, or mechanical obstruction is caused by the enlarged prostate
itself. The dynamic component of the prostate obstruction presumably is related to the
tone of the prostate smooth muscle. Lepor et al. 1989, page 392, column 1, lines 2-10.
4. Surgical removal of the prostate adenoma has been the main treatment of
BPH. Fabricius, page 92, lines 9-10.
5. Transurethral resection and transurethral incision of the prostate have also
been used in the treatment of BPH. In a long-term study, it was shown that the initial
increase in peak urinary flow rate observed after transurethral resection and
transurethral incision of the prostate decreased by approximately 20% and during the
three-year follow-up, whereas the improvements in obstructive and irritative symptom
scores were maintained. After three years, the peak urinary flow rate was only 51%
and 12% greater than baseline values, respectively. Lepor 1992, page 1556, column
2, lines 16-25.
6. The tone of the prostate smooth muscle is dependent on the degree of
activation of the "-adrenoceptors. These adrenoceptors have been shown to be
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