Appeal No. 1997-2182
Application 08/137,443
THE INVENTION
The appealed subject matter is directed to a genus of
compounds which may be broadly characterized as galanthamine
derivatives, a pharmaceutical composition comprising a
pharmaceutically acceptable carrier and an
acetylcholinesterase (AChE) inhibiting amount of the
galanthamine derivative and a method of treating memory
dysfunction characterized by decreased cholinergic function by
administering to a mammal an AChE inhibiting amount of the
galanthamine derivative. According to appellants, the claimed
family of galanthamine derivatives possesses the ability to
inhibit the enzyme AchE. The enzyme AChE lowers acetylcholine
levels in the brain. Inhibition of AChE therefore increases
brain levels of acetylcholine.
Claims 1, 21 and 22 are believed to be adequately
representative of the appealed subject matter and are
reproduced below for a more facile understanding of
appellants' invention.
Claim 1. A compound of the formula
2
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