Ex parte BRYNING et al. - Page 7




          Appeal No. 1997-2569                                                        
          Application No. 08/469,578                                                  


               The examiner recognizes that both Gibbs and Lee fail to                
          teach using electrostatic or acoustic energy to effect the                  
          mixing disclosed therein.  Nevertheless, the examiner                       
          concludes (Answer, pp. 4-5):                                                
                    It would have been obvious to one of ordinary                     
               skill in the art at the time the invention was made                    
               to provide a vibratory agitator in place of the air-                   
               driven agitator in the device of Gibbs because                         
               vibratory agitators achieve mixing in droplets on                      
               moving test strips as taught by Lee.                                   
                    It would have been obvious to one of ordinary                     
               skill in the art at the time the invention was made                    
               to provide a sonic source as the vibratory agitator                    
               in the modified device of Gibbs and Lee because a                      
               sonic source is suitable for reagent mixing by                         
               vibration as taught by Woodbridge.                                     
               Appellants argue that the combination of Gibbs, Lee and                
          Woodbridge proposed by the examiner amounts to a hindsight                  
          reconstruction of the claimed invention.  First, appellants                 
          argue that there is no motivation to use vibratory agitation                
          as in Lee to mix the droplets in Gibbs since Lee uses a gel                 
          which confines the droplets during mixing.  Particularly,                   
          appellants argue (Brief, p. 6):                                             
               The forces acting on the drop of whole blood in Lee                    
               are significantly greater than those found in Gibbs.                   
               The skilled artisan could reasonably conclude that                     
               vibratory mixing of the type used by Lee would not                     
               work for the drop of liquid in Gibbs.                                  

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