Ex parte GLENDENING et al. - Page 4




          Appeal No. 1997-2926                                                        
          Application No. 08/376,299                                                  


          dried microorganisms “overcomes the shortcomings of a culture               
          of microorganisms which are transported from the manufacture                
          to the area of use in a liquid medium (See column 1, line 60                
          to column 2, line 3).”  (Answer, page 9).                                   
               We do not agree that Hoffmann discloses or suggests                    
          “substantially the same” method as recited by the claimed                   
          subject matter.  Hoffmann does not disclose or suggest that                 
          the use of freeze-dried microorganisms “overcomes the                       
          shortcomings” of transporting a liquid medium (see col. 1, ll.              
          60-68).  Hoffmann merely discloses freeze-drying or                         
          lyophilizing as another technique presently used for                        
          preserving the activity of bacteria (col. 1, l. 68-col. 2, l.               
          3).  Furthermore, Hoffmann does not disclose or teach                       
          transporting bacteria in lyophilized form wherein the bacteria              
          are reconstituted at the treatment site (see the Answer, page               
          4).  Hoffmann only discloses that a drawback of freeze-drying               
          bacteria is that the “freeze-dried bacteria need to be                      
          rehydrated prior to achieving optimal activity.”  (Col. 2, ll.              
          13-15).  Hoffmann is silent as to where the rehydration                     
          occurs.  “Where the legal conclusion [of obviousness] is not                


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