Appeal No. 1997-3221 Application No. 08/249,241 establishing a prima facie case of obviousness. In re Oetiker, 977 F.2d 1443, 1446, 24 USPQ2d 1443, 1445 (Fed. Cir. 1992). Having found that the examiner failed to meet his burden of establishing a prima facie case of obviousness in obtaining the NR2A-1 and NR2A-2 protein, the claimed assay method of claim 14 would not have been obvious. In addition, since the examiner failed to meet his burden of establishing a prima facie case of obviousness in obtaining the NR2A-1 and NR2A-2 protein, we need not discuss the NMDAR1 receptor unit used in a heteromeric receptor complex with NR3 protein of claim 21. Where the examiner fails to establish a prima facie case, the rejection is improper and will be overturned. In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir. 1988). Accordingly we reverse the rejection of claims 14, 21 and 22 under 35 U.S.C. § 103 as being unpatentable over Monyer in view of McNamara, Blackstone, Schofield, Grenningloh and Puckett. The rejection of claims 23 and 34: The examiner relies (Answer, page 10) upon Durand for the teaching that the rat NMDAR1 receptor subunit was known to occur in eight splicing variants. However, Durand does not make up for the deficiencies in the combination of Monyer in view of McNamara, Blackstone, Schofield, Grenningloh and Puckett. Where the examiner fails to establish a prima facie case, the rejection is improper and will be overturned. In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir. 1988). 121Page: Previous 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 NextLast modified: November 3, 2007